Introduction Spinal pain can affect the spine as a whole or its individual segments. Lumbar and sacroiliac pain affects about 70% of the world's population, making it a have become a disease of civilization, leading to long-term limitations in human functioning or disability. Aim The purpose of the conducted research is the effectiveness of selected combined therapy procedures during sanatorium treatment in patients with pain in the lumbosacral - sacral spine, their impact on the patients' performance and quality of life. Material and Methods The study was conducted at the Ministry of Interior and Administration rehabilitation medical facility in Kolobrzeg among sanatorium patients participating in 21-day stays in the period from July 2019 to September 2022. The study included 100 patients diagnosed with nonspecific lower back pain syndrome. Patients were randomly divided into two groups of 50. All calculations were performed using STATISTICA 8 to find out if the quality of sanatorium treatment differed according to the treatments selected. The results of the experimental group (combined therapy) were compared with the results of the control group, taking into account pain intensity and assessment of functional capacity. Changes in the level of dependent variables were monitored by two measurements, performed on the same subjects before and after treatment. Results Based on the analysis of the obtained results, it can be concluded that all methods of sanatorium treatment lead to an improvement in the studied parameters, but the use of combined therapy allows to achieve a better therapeutic effect. Conclusions Combined therapy is an effective method of treating lumbosacral spine pain in a sanatorium stay. Combined therapy treatments have shown better therapeutic effects than standard sanatorium treatment offered by the National Health Fund. Combined therapy has the effect of increasing patients' functional status.