Introduction:
Diabetic foot syndrome (DFS) is a severe complication of diabetes that increases the risk of limb amputation and significantly affects quality of life. Effective management requires a comprehensive approach, integrating advanced imaging, accurate microbiological diagnostics, targeted antibiotics, and innovative treatments. This review highlights the latest advancements and emphasizes the importance of an interdisciplinary approach in improving outcomes.

Aim:
This review aims to analyze current strategies for diagnosing, evaluating infection severity, and treating DFS, including antibiotic therapy, surgery, and treatments like negative pressure and hyperbaric oxygen. It provides guidance for clinicians and researchers and identifies areas requiring further research.

Material and Methods:
A literature review was conducted using the PubMed, ResearchGate, Web of Science, and Google Scholar databases, covering the years 1990–2023. Keywords related to the treatment of diabetic foot syndrome were used, including surgical methods, antibiotic therapy, and supportive treatments. Original and review articles published in Polish, English, German, and French were included. Non-peer-reviewed publications and those not addressing therapeutic aspects were excluded.

Results:
Effective management of DFS depends on an integrated approach, combining advanced diagnostics, targeted antibiotic therapy, and innovative wound healing techniques. Surgical precision and a multidisciplinary team are essential to minimize complications and amputations.

Conclusions:
An integrated approach involving early diagnosis, targeted therapy, advanced wound care, and surgical intervention significantly improves outcomes, reducing amputation rates and enhancing the quality of life for DFS patients.