Introduction Multiple sclerosis (MS) is described as a progressive inflammatory chronic disease affecting central nervous system and resulting in severe cognitive and physical disabilities as well as neurological disturbances. Aim The aim of this study was to evaluate the impact of home exercises performed by MS patients (individually adjusted by a physiotherapist) on their quality of life, balance, and functional performance. Material and methods Fifteen patients with MS participated in the study. They were assessed using questionnaires (IADL, WHOQOL-BREF, AIS, MFIS) and functional scales (tandem and single leg stance tests, TUG, 3-Meter Walk Test, The Step Test, 30 s Chair Stand Test, The Five Times Sit-to-Stand Test and Functional Reach Test) before starting the exercises and after several months of self-home exercises. Results A significant improvement in the WHOQOL-BREF domain 4 scores (environmental health, p = 0.031) was observed in the second study. Improvement was also seen in the Timed Up&Go test (p = 0.027), the 3m walk test (p <0.001), and the Five Times Sit-to-Stand Test (p <0.001). Conclusions Self-home exercises by MS patients may improve their functional performance but have little effect on fatigue and disease acceptance. Home exercises should complement traditional rehabilitation.