Aim:
This review aims to collect available publications referring to the diagnosis, prevention, and treatment of OTS in women’s soccer and assess its quality and practical applications and verify whether there are any scientific data analyzing the potential association between OTS and injuries.

Material and Methods:
Relevant articles were selected by computer search in two databases – PubMed and Web of Science – using the keywords ‘over-train’ or ‘overtrain’ and ‘football’ or ‘soccer’. The quality evaluation of included papers was performed.

Results:
A total of 215 records were obtained, but ultimately, only 4 eligible articles were included. Pre-post publications scored a fair quality rating and the case series study scored a good quality rating.

Conclusions:
The diagnostic methods – biomarkers monitoring and performance testing – lack the accuracy, specificity, and repeatability that good-quality clinical trials should have. As for prevention, supplementation and recovery strategies were proposed, but they have no confirmed application in real life. No treatment information and no data analyzing the potential association between OTS and injuries were found. Despite promising results, researchers are still unable to link them directly to OTS, so more studies are needed.